The airline, which is owned by the International Airlines Group IAG, has now cancelled 13 percent of its summer schedule.
BA is among the worst affected by sector-wide turmoil, as carriers race to meet demand after the lifting of Covid travel restrictions.
The airline said in a statement that there were hundreds of flight cancellations this summer because of the fact that the whole aviation industry continues to face a lot of challenges and we're focused on building resilience in order to give customers the certainty they deserve.
The move comes less than two weeks after BA staff at London Heathrow Airport voted to strike over pay this summer because rising inflation erodes wages and sparks growing UK industrial unrest.
More than 90 percent of the Heathrow ground staff voted for walkouts.
Wednesday's news comes after the British government recently offered slot alleviation measures that allow carriers to temporarily reduce schedules while retaining valuable take-off and landing slots.
BA added on Wednesday that while taking further action is not where we wanted to be, it's the right thing to do for our customers and our colleagues.
This new flexibility means that we can further reduce our schedule and consolidate some of our quieter services so that we can protect as many of our holiday flights. The group tried to reassure customers but conceded that it would have a significant impact on travel plans.
BA said most of our flights are unaffected and the majority of customers will get away as planned, but we don't underestimate the impact this will have and we're doing everything we can to get their travel plans back on track.
We're in touch with you to apologise and offer rebooking options for new flights with us or another airline as soon as possible or issue a full refund. In a vote of confidence in the long-term recovery of the aviation sector, IAG ordered 11 Airbus A 320 neo aircraft and three A 321 neos worth $1.7 billion.
The London-listed conglomerate predicted a return to annual profit after the travel curbs were eased, despite narrowing Covid-induced losses.
In 2020 and 2021, the group collapsed into annual losses as Covid ravaged global demand for international air travel, forcing BA and its peers to slash thousands of jobs.
IAG owns various airlines that include Ireland's Aer Lingus and Spain's Iberia.