The latest research findings challenge the previously held belief that a lack of oxygen during birth was a major factor behind cerebral palsy in children. Instead, the study suggests that genetic defects play a crucial role in the development of this neurological disorder. This disorder affects movement and is prevalent among children, manifesting its symptoms in infancy and early childhood.
Cerebral palsy is known to be the most common motor disability in children, and it can also be linked to autism and intellectual impairments. Birth asphyxia, a condition where there is an inadequate supply of oxygen during birth, has long been associated with physical harm, particularly to the brain, and is considered a primary cause of cerebral palsy. However, the new research indicates that genetic mutations are significantly higher in children affected by birth asphyxia, suggesting a potential genetic link to the disorder.
The study, which is considered the largest of its kind regarding cerebral palsy genetics, revealed that a substantial number of Chinese children with cerebral palsy had rare genetic variations. These genetic variations were associated with impaired brain development rather than solely being attributed to a lack of oxygen during birth. Moreover, the research identified 81 mutated genes that contribute to cerebral palsy in affected children, emphasizing the importance of genes that are critical for brain and embryo development. The findings point to a need for early genetic testing in children with cerebral palsy, especially those at risk due to factors like birth asphyxia, to ensure appropriate medical care and tailored treatments.