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The article explores a shift in pain management away from opioids toward new, non-addictive treatments developed by companies like Vertex Pharmaceuticals and Tonix Pharmaceuticals. It highlights Vertex’s recent FDA approval for an acute pain treatment and discusses the promising potential of Tonix’s candidate drug for fibromyalgia, along with the broader outlook for both acute and chronic pain markets.

Cryptocurrency markets are currently in a holding pattern, with prices trading sideways as investors await the impact of upcoming tariff announcements. Despite the cautious sentiment, positive developments such as BlackRock CEO Larry Fink's belief in Bitcoin's potential as a global reserve currency and MicroStrategy's significant Bitcoin purchase suggest a potential for future growth.

The S&P 500 has significantly underperformed global markets in the first quarter of 2023, marking a notable shift from recent years where U.S. stocks dominated. This underperformance is attributed to declining technology stocks and a strong energy sector, leading to revised earnings growth estimates and a surge in gold prices.

Political economist Ed Price believes Elon Musk is being used as a pawn in Donald Trump's political strategy, ultimately becoming a scapegoat for more radical moves. Price also warns that Trump's ambitions could extend beyond the U.S. border and potentially involve foreign policy decisions like ceding Taiwan to China.

Ark Invest, led by Cathie Wood, made significant trades on Monday by purchasing a substantial number of shares in CoreWeave Inc. and Robinhood Markets Inc. The transactions, valued at approximately $3.64 million for CoreWeave and $1.32 million for Robinhood, highlight the firm's continued investment focus despite recent challenges faced by these companies.