AstraZeneca PLC said Tuesday it will collaborate with Ionis Pharmaceuticals Inc. to develop and commercialize the Californian biotechnology company's antisense drug Eplontersen.
The companies will develop and commercialize the drug in the U.S., while AstraZeneca will develop and commercialize Eplontersen in the rest of the world, except for Latin America, it said.
After regulatory approvals, Ionis will get $200 million up front and additional conditional payments of up to $485 million. It will pay up to $2.9 billion of sales-related milestones, royalties, and royalties in the range of a low double-digit to mid-twenties percentage, depending on the region. Eplontersen, currently in phase 3 clinical trials, treats amyloid transthyretin cardiomyopathy, or ATTR-CM, a systemic, progressive and fatal condition that leads to progressive heart failure and death within four years of diagnosis. It also treats amyloid transthyretin polyneuropathy, or ATTR-PN, a disease that causes peripheral nerve damage with motor disability within five years of diagnosis, and is generally fatal within a decade if untreated. Eplontersen's hereditary ATTR-PN treatment is likely to be the first regulatory approval, with the possibility of filing a new drug application with the U.S. Food and Drug Administration by the end of 2022.