Local authorities said at least three people have been killed and five wounded by a Russian missile strike on a residential building in the southern Ukrainian city of Mykolaiv.
Oleksandr Senkevych, mayor, said eight missiles had hit the city, and urged residents to evacuate. Authorities launched a rescue effort to find survivors.
He said the building appeared to have been hit by a Russian X-55 cruise missile.
Photographs from the scene showed smoke billowing from a four-storey building with its upper floor partially destroyed.
Russia hasn't targeted civilian areas during its four-month offensive against Ukraine.
The United Nations says at least 4,700 civilians have been killed since Russia invaded on February 24.
Dozens of people were still missing after a Russian missile strike on a shopping mall in central Ukraine two days ago killed at least 18.
Ukraine said Russia had deliberately killed civilians when it pounded the mall in Kremenchuk.
Moscow said the mall was empty and it had struck a nearby arms depot.
The Russian missile hit this location precisely. Ukraine's President Volodymyr Zelenskyy said in an evening video address that Russian killers received those exact coordinates.
Around 36 people were still missing, according to authorities.
The governor reported increased military action in Lysychansk in the Luhansk region, a key battleground in Russia's assault on the industrial heartland of Donbas.
The situation in Lysychansk is very difficult, said Serhiy Gaidai, the governor of Luhansk.
Russians are using every weapon available to them and not distinguishing whether their targets are military or not: schools, kindergartens, cultural institutions, he said.
In the Dnipropetrovsk region, to the east, Governor Valentyn Reznychenko said Russia had fired six missiles, three of which were shot down.
He said rescue workers were searching for people under rubble in the city of Dnipro.
Separately, Russian-installed officials said their security forces had detained Kherson City Mayor Ihor Kolykhayev after he refused to follow Moscow's orders.
The mayor was abducted, according to a local official.
Kherson, a port city on the Black Sea, is located north-west of the Russian-annexed Crimean peninsula.
In the past few days Ukrainians have also described attacks in the southern Odesa region and Kharkiv in the north-east.
The Russian invasion - the biggest assault on a European state since World War II - has resulted in a rise in food and energy prices and global security worries.